.. include:: /generated/civic.docs-aliases.rst

.. _evidence-direction:

Direction
=========
Evidence Direction indicates if the Evidence Statement supports or refutes the significance of an event. 

Understanding Evidence Direction
--------------------------------
The available options include: “Supports” or “Does Not Support”. Nuanced examples for how to correctly use the Evidence Direction for Predictive Evidence Types are shown in the :ref:`section on curating Evidence Items <curating-evidence>`. 

Curating Evidence Direction
---------------------------
Evidence Direction interpretation differs slightly depending on the Evidence Type. 

.. rubric:: Direction for Predictive Evidence
.. list-table::
   :widths: 25 5 70
   :header-rows: 1
   :class: cvc-icon-table

   * - Direction
     - Icon
     - Definition
   * - Supports
     - |attribute-supports|
     - Experiment or study supports the variant's response to a drug
   * - Does not support
     - |attribute-doesnotsupport|
     - Experiment or study does not support, or was inconclusive of an interaction between the variant and a drug


.. rubric:: Direction for Diagnostic Evidence
.. list-table::
   :widths: 25 5 70
   :header-rows: 1
   :class: cvc-icon-table

   * - Direction
     - Icon
     - Definition
   * - Supports
     - |attribute-supports|
     - Experiment or study supports the variant's impact on the diagnosis of disease or subtype
   * - Does not support
     - |attribute-doesnotsupport|
     - Experiment or study does not support the variant's impact on diagnosis of disease or subtype

.. rubric:: Direction for Prognostic Evidence
.. list-table::
   :widths: 25 5 70
   :header-rows: 1
   :class: cvc-icon-table

   * - Direction
     - Icon
     - Definition
   * - Supports
     - |attribute-supports|
     - Experiment or study supports the variant's impact on prognostic outcome
   * - Does not support
     - |attribute-doesnotsupport|
     - Experiment or study does not support a prognostic association between variant and outcome

.. rubric:: Direction for Predisposing Evidence (where Significance is Predisposition)
.. list-table::
   :widths: 25 5 70
   :header-rows: 1
   :class: cvc-icon-table

   * - Direction
     - Icon
     - Definition
   * - Supports
     - |attribute-supports|
     - Suggests a pathogenic or a protective role for a germline variant in cancer
   * - Does not support
     - |attribute-doesnotsupport|
     - Supports a benign (for Predisposition) or lack of protective (for Protectiveness) role for a germline variant in cancer.

.. rubric:: Direction for Functional Evidence
.. list-table::
   :widths: 25 5 70
   :header-rows: 1
   :class: cvc-icon-table

   * - Direction
     - Icon
     - Definition
   * - Supports
     - |attribute-supports|
     - Experiment or study supports the variant causing alteration or non-alteration of the gene product function
   * - Does not support
     - |attribute-doesnotsupport|
     - Experiment or study does not support the variant causing alteration or non-alteration of the gene product function

.. rubric:: Direction for Oncogenic Evidence (where Significance is Oncogenicity)
.. list-table::
   :widths: 25 5 70
   :header-rows: 1
   :class: cvc-icon-table

   * - Direction
     - Icon
     - Definition
   * - Supports
     - |attribute-supports|
     - Supports an oncogenic or protective role for a somatic variant.
   * - Does not support
     - |attribute-doesnotsupport|
     - Supports a benign (for Oncogenicity) or lack of protective (for Protectiveness) role for a somatic variant in cancer.
   * - Not Applicable
     - |attribute-na|
     - Not applicable for Oncogenic Evidence Type