Assertions¶
The assertions endpoint allows users to enumerate all of the assertions present in CIViC as well as retrieve more detailed information on a specific assertion. This is the endpoint that should be used to obtain a complete listing of every assertion in CIViC.
Get a list of assertions¶
This endpoint returns a listing of assertions in CIViC. This index style endpoint is paginated by default. You can use the count and page parameters or the previous and next links to iterate through all the assertions.
HTTP Request Format
GET https://civicdb.org/api/assertions
Query Parameters
Parameter |
Default |
Description |
|---|---|---|
page |
1 |
Which page of results to return |
count |
25 |
How many assertions to return on a single page |
Example Request
curl https://civicdb.org/api/assertions?count=1
Example Response
{
"_meta": {
"current_page": 1,
"per_page": "1",
"total_pages": 48,
"total_count": 48,
"links": {
"next": "https://v1.civicdb.org/api/assertions?count=1&page=2",
"previous": null
}
},
"records": [
{
"id": 1,
"type": "assertion",
"name": "AID1",
"summary": "HER2 amplification predicts sensitivity to Trastuzumab",
"description": "HER2 amplification defines a clinically relevant subtype of breast cancer. HER2 amplification predicts sensitivity to various targeted therapies including the monoclonal antibody Trastuzumab. The use of Trastuzumab, often in combination with chemotherapy and/or endocrine therapy (depending on hormone receptor status), is now standard of care for HER2-positive breast cancer patients.",
"gene": {
"name": "ERBB2",
"id": 20
},
"variant": {
"name": "Amplification",
"id": 18
},
"disease": {
"id": 368,
"name": "Her2-receptor Positive Breast Cancer",
"display_name": "Her2-receptor Positive Breast Cancer",
"doid": "0060079",
"url": "http://disease-ontology.org/?id=DOID:0060079"
},
"drugs": [
{
"id": 84,
"name": "Trastuzumab",
"ncit_id": "C1647",
"aliases": []
}
],
"evidence_type": "Predictive",
"evidence_direction": "Supports",
"clinical_significance": "Sensitivity/Response",
"evidence_item_count": 3,
"fda_regulatory_approval": true,
"status": "rejected",
"open_change_count": 0,
"pending_evidence_count": 0,
"flagged": false,
"updated_at": "2020-01-16T19:05:22.127Z"
}
]
}
Get details for a specific assertion¶
This endpoint retrieves details about a specific assertion, given its internal CIViC id.
HTTP Request Format
GET https://civicdb.org/api/assertions/:id
Example Request
curl https://civicdb.org/api/assertions/9
Example Response
{
"id": 9,
"type": "assertion",
"name": "AID9",
"summary": "Supports diagnosis of diffuse intrinsic pontine glioma.",
"description": "ACVR1 G328V mutations occur within the kinase domain, leading to activation of downstream signaling. Exclusively seen in high-grade pediatric gliomas, supporting diagnosis of diffuse intrinsic pontine glioma.",
"gene": {
"name": "ACVR1",
"id": 154
},
"variant": {
"name": "G328V",
"id": 1686
},
"disease": {
"id": 2950,
"name": "Diffuse Midline Glioma, H3 K27M-mutant",
"display_name": "Diffuse Midline Glioma, H3 K27M-mutant",
"doid": "0080684",
"url": "http://disease-ontology.org/?id=DOID:0080684"
},
"drugs": [],
"evidence_type": "Diagnostic",
"evidence_direction": "Supports",
"clinical_significance": "Positive",
"evidence_item_count": 2,
"fda_regulatory_approval": false,
"status": "accepted",
"open_change_count": 0,
"pending_evidence_count": 0,
"flagged": false,
"updated_at": "2018-10-16T17:06:39.465Z",
"nccn_guideline": null,
"nccn_guideline_version": "",
"amp_level": "Tier II - Level C",
"evidence_items": [
{
"id": 4846,
"name": "EID4846",
"description": "Sequencing of 39 pediatric midline high-grade astrocytomas identified 5 patients with ACVR1 mutations. The authors identified an increase in endogenous phospho-SMAD1/5/8 signal in diffuse intrinsic pontine glioma (DIPG) cells harboring ACVR1 G328V, with corresponding increase in phospho-SMAD1/5/8 staining as well. By PCR, the authors show strong increase in fold change of mRNA expression in downstream proteins of the ACVR1/BMP pathway, ID, ID2, ID3 and SNAI1 in ACVR1-mutant DIPG cell line compared to glioblastoma cells (KNS42 cells). These activating ACVR1 mutations were exclusively in midline high grade astrocytomas (P = 0.0040, Fisher's exact test).",
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"id": 2950,
"name": "Diffuse Midline Glioma, H3 K27M-mutant",
"display_name": "Diffuse Midline Glioma, H3 K27M-mutant",
"doid": "0080684",
"url": "http://disease-ontology.org/?id=DOID:0080684"
},
"drugs": [],
"rating": 3,
"evidence_level": "B",
"evidence_type": "Diagnostic",
"clinical_significance": "Positive",
"evidence_direction": "Supports",
"variant_origin": "Somatic",
"drug_interaction_type": null,
"status": "accepted",
"open_change_count": 0,
"type": "evidence",
"source": {
"id": 2149,
"name": "Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.",
"citation": "Fontebasso et al., 2014, Nat. Genet.",
"citation_id": "24705250",
"source_type": "PubMed",
"asco_abstract_id": null,
"source_url": "http://www.ncbi.nlm.nih.gov/pubmed/24705250",
"open_access": true,
"pmc_id": "PMC4282994",
"publication_date": {
"year": 2014,
"month": 5
},
"journal": "Nat. Genet.",
"full_journal_title": "Nature genetics",
"status": "partially curated",
"is_review": false,
"clinical_trials": []
},
"flagged": false,
"variant_id": 1686,
"phenotypes": [],
"updated_at": "2018-10-16T16:57:05.438Z",
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{
"id": 9,
"type": "assertion",
"name": "AID9",
"summary": "Supports diagnosis of diffuse intrinsic pontine glioma.",
"description": "ACVR1 G328V mutations occur within the kinase domain, leading to activation of downstream signaling. Exclusively seen in high-grade pediatric gliomas, supporting diagnosis of diffuse intrinsic pontine glioma.",
"gene": {
"name": "ACVR1",
"id": 154
},
"variant": {
"name": "G328V",
"id": 1686
},
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"name": "Diffuse Midline Glioma, H3 K27M-mutant",
"display_name": "Diffuse Midline Glioma, H3 K27M-mutant",
"doid": "0080684",
"url": "http://disease-ontology.org/?id=DOID:0080684"
},
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"evidence_type": "Diagnostic",
"evidence_direction": "Supports",
"clinical_significance": "Positive",
"evidence_item_count": 2,
"fda_regulatory_approval": false,
"status": "accepted",
"open_change_count": 0,
"pending_evidence_count": 0,
"flagged": false,
"updated_at": "2018-10-16T17:06:39.465Z"
}
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