Direction¶
Evidence Direction indicates if the Evidence Statement supports or refutes the significance of an event.
Understanding Evidence Direction¶
The available options include: “Supports” or “Does Not Support”. Nuanced examples for how to correctly use the Evidence Direction for Predictive Evidence Types are shown in the section on curating Evidence Items.
Curating Evidence Direction¶
Evidence Direction interpretation differs slightly depending on the Evidence Type.
Direction for Predictive Evidence
Direction |
Symbol |
Definition |
---|---|---|
Supports |
The experiment or study supports this variant’s response to a drug |
|
Does not support |
The experiment or study does not support, or was inconclusive of an interaction between the variant and a drug |
Direction for Diagnostic Evidence
Direction |
Symbol |
Definition |
---|---|---|
Supports |
The experiment or study supports variant’s impact on the diagnosis of disease or subtype |
|
Does not support |
The experiment or study does not support the variant’s impact on diagnosis of disease or subtype |
Direction for Prognostic Evidence
Direction |
Symbol |
Definition |
---|---|---|
Supports |
The experiment or study supports a variant’s impact on prognostic outcome |
|
Does not support |
The experiment or study does not support a prognostic association between variant and outcome |
Direction for Predisposing Evidence (where Significance is Predisposition)
Direction |
Symbol |
Definition |
---|---|---|
Supports |
The experiment or study may contribute to a pathogenic classification (final determination at the Assertion level) |
|
Does not support |
The experiment or study may contribute to a benign classification (final determination at the Assertion level) |
Direction for Oncogenic Evidence (where Significance is Oncogenicity)
Direction |
Symbol |
Definition |
---|---|---|
Supports |
The experiment or study may contribute to an oncogenic classification (final determination at the Assertion level) |
|
Does not support |
The experiment or study may contribute to a benign classification (final determination at the Assertion level) |
Direction for Functional Evidence
Direction |
Symbol |
Definition |
---|---|---|
Supports |
The experiment or study supports this variant causing alteration or non-alteration of the gene product function |
|
Does not support |
The experiment or study does not support this variant causing alteration or non-alteration of the gene product function |