Direction

Evidence Direction indicates if the Evidence Statement supports or refutes the significance of an event.

Understanding Evidence Direction

The available options include: “Supports” or “Does Not Support”. Nuanced examples for how to correctly use the Evidence Direction for Predictive Evidence Types are shown in the section on curating Evidence Items.

Curating Evidence Direction

Evidence Direction interpretation differs slightly depending on the Evidence Type.

Direction for Predictive Evidence

Direction	Symbol	Definition
Supports		The experiment or study supports this variant’s response to a drug
Does not support		The experiment or study does not support, or was inconclusive of an interaction between the variant and a drug

Direction for Diagnostic Evidence

Direction	Symbol	Definition
Supports		The experiment or study supports variant’s impact on the diagnosis of disease or subtype
Does not support		The experiment or study does not support the variant’s impact on diagnosis of disease or subtype

Direction for Prognostic Evidence

Direction	Symbol	Definition
Supports		The experiment or study supports a variant’s impact on prognostic outcome
Does not support		The experiment or study does not support a prognostic association between variant and outcome

Direction for Predisposing Evidence (where Significance is Predisposition)

Direction	Symbol	Definition
Supports		The experiment or study may contribute to a pathogenic classification (final determination at the Assertion level)
Does not support		The experiment or study may contribute to a benign classification (final determination at the Assertion level)

Direction for Oncogenic Evidence (where Significance is Oncogenicity)

Direction	Symbol	Definition
Supports		The experiment or study may contribute to an oncogenic classification (final determination at the Assertion level)
Does not support		The experiment or study may contribute to a benign classification (final determination at the Assertion level)

Direction for Functional Evidence

Direction	Symbol	Definition
Supports		The experiment or study supports this variant causing alteration or non-alteration of the gene product function
Does not support		The experiment or study does not support this variant causing alteration or non-alteration of the gene product function