Direction

Evidence Direction indicates if the Evidence Statement supports or refutes the significance of an event.

Understanding Evidence Direction

The available options include: “Supports” or “Does Not Support”. Nuanced examples for how to correctly use the Evidence Direction for Predictive Evidence Types are shown in the section on curating Evidence Items.

Curating Evidence Direction

Evidence Direction interpretation differs slightly depending on the Evidence Type.

Direction for Predictive Evidence

Direction	Icon	Definition
Supports		Experiment or study supports the variant’s response to a drug
Does not support		Experiment or study does not support, or was inconclusive of an interaction between the variant and a drug

Direction for Diagnostic Evidence

Direction	Icon	Definition
Supports		Experiment or study supports the variant’s impact on the diagnosis of disease or subtype
Does not support		Experiment or study does not support the variant’s impact on diagnosis of disease or subtype

Direction for Prognostic Evidence

Direction	Icon	Definition
Supports		Experiment or study supports the variant’s impact on prognostic outcome
Does not support		Experiment or study does not support a prognostic association between variant and outcome

Direction for Predisposing Evidence (where Significance is Predisposition)

Direction	Icon	Definition
Supports		Suggests a pathogenic or a protective role for a germline variant in cancer
Does not support		Supports a benign (for Predisposition) or lack of protective (for Protectiveness) role for a germline variant in cancer.

Direction for Functional Evidence

Direction	Icon	Definition
Supports		Experiment or study supports the variant causing alteration or non-alteration of the gene product function
Does not support		Experiment or study does not support the variant causing alteration or non-alteration of the gene product function

Direction for Oncogenic Evidence (where Significance is Oncogenicity)

Direction	Icon	Definition
Supports		Supports an oncogenic or protective role for a somatic variant.
Does not support		Supports a benign (for Oncogenicity) or lack of protective (for Protectiveness) role for a somatic variant in cancer.
Not Applicable		Not applicable for Oncogenic Evidence Type