Type¶
The Evidence Type refers to the type of clinical (or biological) association described by the Evidence Item’s clinical summary.
Understanding Evidence Types¶
Six Evidence Types are currently supported: Predictive (i.e. Therapeutic), Diagnostic, Prognostic, Predisposing, Oncogenic, and Functional. Each Evidence Type describes the clinical or biological effect a Molecular Profile (MP) has on the following: therapeutic response (Predictive), determining a patient’s diagnosis or disease subtype (Diagnostic), predicting disease progression or patient survival (Prognostic), disease susceptibility (Predisposing), or biological alterations relevant to a cancer phenotype (Oncogenic) or protein function (Functional). Selecting an Evidence Type has implications on available selections for Significance, which are detailed on the Evidence Significance page.
Type |
Symbol |
Definition |
---|---|---|
Predictive |
Evidence pertaining to a Molecular Profile’s effect on therapeutic response |
|
Diagnostic |
Evidence pertaining to a Molecular Profile’s impact on patient diagnosis |
|
Prognostic |
Evidence pertaining to a Molecular Profile’s impact on disease progression, severity, or patient survival |
|
Predisposing |
Evidence pertains to a germline Molecular Profile’s role in conferring susceptibility to disease (including pathogenicity evaluations) |
|
Oncogenic |
Evidence pertains to a somatic Molecular Profile’s involvement in tumor pathogenesis as described by the Hallmarks of Cancer |
|
Functional |
Evidence pertains to a Molecular Profile’s impact on gene product (e.g. protein) function |
Extensive documentation for curating Evidence types is provided on the Curating Evidence page. Be sure to closly study the examples for each type.